ESR 11 position
MSCA ITN founded project “DohART-NET” focusing on effect of altered conditions during the periconceptional (PC) period of development in humans, including babies born from assisted reproduction (ART, “test-tube”) interventions, and from diabetic, obese mothers. The DohART-NET project integrates pre-clinical (animal and stem cell-models) and clinical studies and apply data linkage, bioinformatics and network science for the identification and validation of mechanisms of diseases common in early development. The project will promote efficient disease prevention and potential personalised therapeutic interventions in both the general and ART populations to overcome adverse disease pathways. DohART-NET will train 13 Early Stage Researchers (ESRs) PhD students on this important topic much needed to improve public health over several generations, and it will integrate pre-clinical, translational clinical and in silico modeling approaches. The ESRs will strongly benefit from a network of internationally recognized scientists and the participation of companies with relevant interests and expertise in the field.
DohART-NET Network: BioTalentum Ltd. (Hungary), University of Cambridge (UK), University of Manchester (UK), University of Southampton (UK), Erasmus University Medical Center (Netherlands), CeMM (Austria), Ludwig Maximilian University of Munich (Germany), MWM GmbH (Germany), Universitair Ziekenhuis Brussel (Belgium), IVI Valencia (Spain)
Job Title: PhD Position (ESR11)
Application Deadline: 25th October 2019
Recruiting Institution: MWM GmbH – Munich, DE
DohART-NET is focusing on effects of altered conditions during the periconceptional (PC) period and integrates pre-clinical (animal and stem cell models) and clinical studies.
The applicant of ESR11 project will focus on effects of maternal diabetes on beta-cell function on the Islets of Langerhans of offspring from genetically (pre-)diabetic sows vs. healthy sows in clinical relevant large animal pig models, to assess the developmental programming effects of diabetes. The project comprises functional evaluation of beta-cell function in situ on pancreatic tissue slices as well as in vitro on isolated islets. This project encompasses e.g. stimulated insulin secretion assays, ELISAs, immunofluorescent and immunohistochemical analyses of vibratome and microtome slices as well as RNA and protein analyses.
The project implies a series of secondments at partner labs as well as regular workshops for additional training. The candidate will strongly benefit from a network of internationally recognized scientists and the participation of companies with relevant interests and expertise in the field.
The ideal candidate should have a background in veterinary medicine or should be a master in molecular biology, biotechnology, or equivalent. We are looking for a highly motivated candidate who should have solid knowledge in physiology and molecular biology. Practical sterile work and cell culture experience, together with molecular biology and imaging competencies, are strongly preferred but not mandatory.
Eligibility (mandatory for funding):
- Have not been awarded a PhD already
- Less than 4 years research experience at the signature of the contract (counting from the time the Master’s degree has been obtained)
- Spent less than 12 months in Germany in the 3 years prior to selection
- Excellent knowledge of the spoken and written English language
- Excellent communication and team working skills
How to Apply and further details:
Follow the below steps to submit your application. Please note all the uploaded documents should be written in English and should be in PDF format.
1. Please answer the questions below
2. Fill in the required fields
3. Upload your CV
4. Upload your motivation letter describing research career goals, skills and experience
5. Upload 2 letters of recommendation