Ludwig Maximilian University of Munich
The LMU Munich is the top-ranked and largest university in Germany, covering a full catalogue of subjects. In 2006 it was one of the first three universities, which were awarded the status of an Excellence University, which is hold until today.
Short biography principal investigator
Dr. Thomas Fröhlich
Dr. Thomas Fröhlich is head of the proteomics unit in the Laboratory for Functional Genome Analysis LAFUGA and has more than 15 years of experience in quantitative proteomic analysis with a focus on early embryonic development, mammalian reproductive tissues and genetically tailored large animal models.
Key persons involved
Prof. Dr. Eckhard Wolf
Prof. Dr. Eckhard Wolf, directs the Institute of Molecular Animal Breeding and Biotechnology (since 1995), the Laboratory for Functional Genome Analysis (LAGUGA; since 2003), and the Centre for Innovative Medical Models (CiMM; since 2015) at the Gene Centre and the Department of Veterinary Sciences of the LMU Munich. He is Vice-Dean for Research at the Faculty of Veterinary Medicine of LMU Munich (since 2008), Member of the Leopoldina – German National Academy of Sciences (since 2000), and Corresponding member of the Austrian Academy of Sciences (ÖAW; since 2014). EW is Action Chair of COST Action BM1308 “Sharing Advances on Large Animal Models – SALAAM” which provides interesting training opportunities, such as Short-Term Scientific Missions (STSMs) and Training Schools (see www.salaam.genzentrum.lmu.de) which will also be open for DOHART-NET students. EW has long-standing experience in the generation and characterisation of genetically tailored biomedical pig models, especially for diabetes research and for xenotransplantation. He will provide the academic environment for student(s) at MWM Biomodels GmbH and the scientific supervision of the project.
Key Research Facility and Equipment
LMU participates with the Laboratory for Functional Genome Analysis (LAFUGA), an integrated technology platform with the units Animal Models, Genomics, and Proteomics at the Gene Center Munich (www.genzentrum.lmu.de; Director: E. Wolf). LAFUGA’s proteome unit (Head: Dr. Thomas Fröhlich) is focused on quantitative proteome approaches in mammalian tissues. State-of-the-art equipment is available at LAFUGA’s proteome unit including high-end nano-LC-ESI mass spectrometers (e.g., Thermo Q Exactive HF-X, SCIEX Triple-TOF SCIEX 5600), and a SCIEX Q-TRAP instrument for targeted protein quantification assays by multiplexed „Selected Reaction Monitoring“ (mSRM) for Biomarker development. All bioinformatics hardware and software tools for proteome data evaluation are available. LAFUGA has 380 m2 research facilities.
Current involvement in Research and Training Programmes
Thomas Fröhlich is a project leader in the Collaborative Research Centre 1357 “MICROPLASTICS” (coord. Prof. Laforsch) and trainer in COST Actions BM1308 (Chair: Prof. Wolf) and FA 1205 (Chair: Dr. Asturiano).
- Wolf (Director of LAFUGA) is a member of the Excellence Graduate School QBM (Quantitative Biosciences Munich), which provides interdisciplinary training at the interface of experiment and theoretical analysis for young life scientists. Drawing on a range of disciplines represented at LMU, including biochemistry, bioinformatics, structural biology, medicine, physics and mathematics, the School will equip students with the skills necessary for modern quantitative, systems- oriented bioscience (http://www.qbm.genzentrum.lmu.de/). Some of the modules, such as QBM lecture series, seminars etc. will be open for DOHART-NET students. In addition the LMU Graduate Centre offers a broad range of courses in soft skills such as presentation techniques, time management etc. (see http://www.en.graduatecenter.uni-muenchen.de/index.html).
International: E. Wolf is also Action Chair of COST Action BM1308, which includes interesting training opportunities on large animal models.